| CDKN2B |
| LOCUS ID | 1030 | ||||||||||
| GENE_SYMBOL | CDKN2B | ||||||||||
| GENE NAME | cyclin dependent kin | ||||||||||
| SYNONYMNS | P15,MTS2,TP15,CDK4I,INK4B,p15INK4b | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 55859 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Atherosclerosis | Thus, atherosclerosis complications in T2DM associate with altered immune cell homeostasis, diminished CDKN2A/2B/2BAS expression, and increased CDK4 levels. The present study also suggests that the treatment with drugs that mimic CDKN2A/2B genes could potential be considered as a promising therapy to delay atherosclerosis | 30176239 |