| CDKN2BAS |
| LOCUS ID | 100048912 | ||||||||||
| GENE_SYMBOL | CDKN2BAS | ||||||||||
| GENE NAME | CDKN2B antisense RNA | ||||||||||
| SYNONYMNS | ANRIL, p15AS, PCAT12, CDKN2BAS, CDKN2B-AS, NCRNA00089 | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 0 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer&ap |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Atherosclerosis | 1. Thus, atherosclerosis complications in T2DM associate with altered immune cell homeostasis, diminished CDKN2A/2B/2BAS expression, and increased CDK4 levels. | 30176239 |