CDKN2BAS
LOCUS ID100048912
GENE_SYMBOLCDKN2BAS
GENE NAMECDKN2B antisense RNA
SYNONYMNSANRIL, p15AS, PCAT12, CDKN2BAS, CDKN2B-AS, NCRNA00089
CHROMOSOME9
HOMOLOGENE ID0
microRNAsNANA
GENE SUMMARY
This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer&ap

OBSERVATIONS

Complication Evidence PMID
Atherosclerosis1. Thus, atherosclerosis complications in T2DM associate with altered immune cell homeostasis, diminished CDKN2A/2B/2BAS expression, and increased CDK4 levels.30176239