| CERK |
| LOCUS ID | 64781 | ||||||||||
| GENE_SYMBOL | CERK | ||||||||||
| GENE NAME | ceramide kinase | ||||||||||
| SYNONYMNS | LK4 hCERK dA59H18.2 dA59H18.3 | ||||||||||
| CHROMOSOME | 22 | ||||||||||
| HOMOLOGENE ID | 11247 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We determined that CERK deficiency suppresses diet-induced increases in body weight, and improves glucose intolerance. | 22465662 |