| CES2 |
| LOCUS ID | 8824 | ||||||||||
| GENE_SYMBOL | CES2 | ||||||||||
| GENE NAME | carboxylesterase 2 | ||||||||||
| SYNONYMNS | iCE CE-2 PCE-2 CES2A1 | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 128645 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternativ |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. In primary human hepatocytes, CES2 knockdown impaired glucose storage and lipid oxidation. | 28099843 |