| CHIT1 |
| LOCUS ID | 1118 | |||||||||||||
| GENE_SYMBOL | CHIT1 | |||||||||||||
| GENE NAME | chitinase 1 | |||||||||||||
| SYNONYMNS | CHI3,CHIT,CHITD | |||||||||||||
| CHROMOSOME | 1 | |||||||||||||
| HOMOLOGENE ID | 68318 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The immunomodulatory effects of chitotriosidase enzyme could be implicated in the development of nephropathy in type 2 diabetes. | 26589000 |
| Insulin resistance and inflammation | 1. CHIT1 is expressed by adipose tissue macrophages and expression is higher in overweight subjects and T2D patients, indicating its potential as tissue biomarker for adipose tissue inflammation. | 30301968 |