| CITED2 |
| LOCUS ID | 10370 | ||||||||||
| GENE_SYMBOL | CITED2 | ||||||||||
| GENE NAME | Cbp/p300 interacting | ||||||||||
| SYNONYMNS | ASD8 MRG1 VSD2 MRG-1 P35SRJ | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 4433 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. In patients with atherosclerotic complications of diabetes, impaired neovascularization of ischemic tissue in the myocardium and lower limb limits the ability of these tissues to compensate for poor perfusion. We conclude that vascular insulin resistance in type 2 diabetes contributes to the upregulation of CITED2, which impairs HIF signaling and endothelial proangiogenic function. | 27561725 |