| CMC4 |
| LOCUS ID | 100272147 | ||||||||||
| GENE_SYMBOL | CMC4 | ||||||||||
| GENE NAME | C-x(9)-C motif conta | ||||||||||
| SYNONYMNS | p8, C6.1B, MTCP1, MTCP1B, MTCP1NB, p8MTCP1 | ||||||||||
| CHROMOSOME | X | ||||||||||
| HOMOLOGENE ID | 106257 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the downstream 8 kDa protein that localizes to mitochondria. |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Our transcriptional profiling studies have revealed that the p8 gene, which encodes a putative basic helix-loop-helix protein, is strongly induced in ET-1-treated renal mesangial cells and in an animal model of diabetic nephropathy 2. Thus, p8 is a novel marker for diabetic renal hypertropy. | 15016802 |