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CNDP1 |
LOCUS ID | 84735 | ||||||||||||||||
GENE_SYMBOL | CNDP1 | ||||||||||||||||
GENE NAME | carnosine dipeptidas | ||||||||||||||||
SYNONYMNS | CN1, CPGL2, HsT2308 | ||||||||||||||||
CHROMOSOME | 18 | ||||||||||||||||
HOMOLOGENE ID | 57178 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. polymorphisms within the carnosine dipeptidase 1 gene (CNDP1), located on 18q22. 3, have been shown to be associated with diabetic nephropathy in European subjects with type 2 diabetes. | 23342076 |
Cardiovascular | 1. There was a significant interaction between CNDP1 and sex for the association with cardiovascular mortality (p = 0.01), not for all-cause mortality (p = 0.32). The association between CNDP1 and cardiovascular mortality was sex-specific, with a higher risk in women with 5L-5L genotype. | 24756973 |
Neuropathy | 1. CNDP1, NOS3, and MnSOD Polymorphisms as Risk Factors for Diabetic Nephropathy among Type 2 Diabetic Patients in Malaysia. | 30719346 |