| COG2 |
| LOCUS ID | 22796 | ||||||||||
| GENE_SYMBOL | COG2 | ||||||||||
| GENE NAME | component of oligome | ||||||||||
| SYNONYMNS | LDLC | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 7206 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Altertive splicing results in multiple transcript variants.[provided by RefSeq, F |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. The lipid profile in patients with type 2 DM is characterized by elevated triglycerides, low levels of high-density lipoprotein cholesterol, and small dense low-density lipoprotein cholesterol (LDLC) particles and is believed to be a key factor promoting atherosclerosis in these patients | 17547840 |