| CPT1A |
| LOCUS ID | 1374 | ||||||||||
| GENE_SYMBOL | CPT1A | ||||||||||
| GENE NAME | carnitine palmitoylt | ||||||||||
| SYNONYMNS | CPT1 CPT1-L L-CPT1 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 1413 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. CPT1A protected against fatty acid-induced insulin resistance and expression of pro-inflammatory adipokines such as TNF-? (tumour necrosis factor-?) and IL-6 (interleukin-6) in adipocytes. | 21348853 |