| CPVL |
| LOCUS ID | 54504 | ||||||||||
| GENE_SYMBOL | CPVL | ||||||||||
| GENE NAME | carboxypeptidase, vi | ||||||||||
| SYNONYMNS | HVLP | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 80235 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. At least two altertively spliced transcripts which encode the same protein have been observed. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. We identified 34 replicated genetic variants. Of these, 21 remained significantly associated with diabetic nephropathy in a random-effects meta-alysis. These variants were in or near the following genesACE, AKR1B1 (two variants), APOC1, APOE, EPO, NOS3 (two variants), HSPG2, VEGFA, FRMD3 (two variants), CARS (two variants), UNC13B, CPVL and CHN2, and GREM1, plus four variants not near genes. The odds ratios of associated genetic variants ranged from 0.48 to 1.70. additional variants were detected in subgroup alysesELMO1 (Asians), CCR5 (Asians) and CNDP1 (type 2 diabetes). | 21127830 |