| CRH |
| LOCUS ID | 1392 | |||||||||||||
| GENE_SYMBOL | CRH | |||||||||||||
| GENE NAME | corticotropin releas | |||||||||||||
| SYNONYMNS | CRF, CRH1 | |||||||||||||
| CHROMOSOME | 8 | |||||||||||||
| HOMOLOGENE ID | 599 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer' |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. When peak ACTH responses to CRH and basal cortisol levels were combined, a significant negative correlation was found (r = .545, P < .02). These data show that even uncomplicated diabetes mellitus is associated with adrel hyperfunction. Such an alteration is more pronounced in the presence of neuropathy | 7723679 |
| Insulin resistance and inflammation | 1. we report here that CRH can act directly on skeletal muscle to stimulate thermogenesis, an effect that is more pronounced in oxidative than in glycolytic muscles and that can be inhibited by a selective CRH-R2 antagonist or blunted by a nonselective CRH receptor antagonist. | 16210362 |