| CSRP3 |
| LOCUS ID | 8048 | ||||||||||
| GENE_SYMBOL | CSRP3 | ||||||||||
| GENE NAME | cysteine and glycine | ||||||||||
| SYNONYMNS | CLP MLP CRP3 LMO4 CMD1M CMH12 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 20742 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. High-fat diet-fed CSRP3 knockout (KO) mice developed impaired glucose tolerance and insulin resistance as well as increased inflammation in skeletal muscle compared with wild-type (WT) mice. | 29634311 |