| CST2 |
| LOCUS ID | 1470 | ||||||||||
| GENE_SYMBOL | CST2 | ||||||||||
| GENE NAME | cystatin SA | ||||||||||
| SYNONYMNS | NA | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 88653 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Serum cystatin SA level could reflect kidney function and thus may serve as a biomarker for DN and other forms of nephropathy | 31174096 |