| CST3 |
| LOCUS ID | 1471 | ||||||||||||||||
| GENE_SYMBOL | CST3 | ||||||||||||||||
| GENE NAME | cystatin C | ||||||||||||||||
| SYNONYMNS | ARMD11, HEL-S-2 | ||||||||||||||||
| CHROMOSOME | 20 | ||||||||||||||||
| HOMOLOGENE ID | 78 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteise inhibitors found in a variety of human fluids and secretions, where they a |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. In , cystatin C level was significantly associated with insulin resistance and biomarkers reflecting inflammation independent of renal function. These components may have a role in addition to that of eGFR in explaining the link between cystatin C and CVD in type 2 diabetes mellitus patients | 19765773 |
| Nephropathy | 1. Urinary biomarkers cystatin C [Cys C]) was significantly elevated in normoalbuminuric type 2 diabetic patients compared with nondiabetic controls and could be used as markers of nephropathy at a very early stage even before the development of microalbuminuria, the current gold standard for early diagnosis. | 28671149 |
| Atherosclerosis | 1. Serum cystatin C is associated with subclinical atherosclerosis in patients with type 2 diabetes | 29090609 |