| CTSH |
| LOCUS ID | 1512 | ||||||||||
| GENE_SYMBOL | CTSH | ||||||||||
| GENE NAME | cathepsin H | ||||||||||
| SYNONYMNS | ACC4, ACC5, CPSB, ACC-4, ACC-5, minichain | ||||||||||
| CHROMOSOME | 15 | ||||||||||
| HOMOLOGENE ID | 36159 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a lysosomal cysteine proteise important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignt progression of prostate tumors. Alterte splicing of this gen |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. In , CTSH/rs3825932 and ERBB3/rs2292239 SNPs were associated with reduced risk of progression to PDR and two-step progression of DR on the ETDRS scale accordingly. | 26245339 |