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CX3CL1 |
LOCUS ID | 6376 | ||||||||||||||||
GENE_SYMBOL | CX3CL1 | ||||||||||||||||
GENE NAME | chemokine (C-X3-C mo | ||||||||||||||||
SYNONYMNS | NTN, NTT, CXC3, CXC3C, SCYD1, ABCD-3, C3Xkine, fra | ||||||||||||||||
CHROMOSOME | 16 | ||||||||||||||||
HOMOLOGENE ID | 2251 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemota |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. Fractalkine and CX3CR1 upregulation were demonstrated in an early stage of diabetic kidney. These upregulation, as well as urinary albumin excretion, were suppressed by treatments with temocapril and aminoguanidine for 8 weeks. These findings suggest that fractalkine expression and CX3CR1-positive cell infiltration in diabetic kidneys might play an important role for progression of diabetic nephropathy. | 15153757 |
Cardiovascular | 1. Circulating CX3CL1 level may contribute to both atherosclerotic CVD and diabetes in a CKD cohort. | 25795074 |
Insulin resistance and inflammation | 1. The association of CX3CL1 and SFRP4 with low-grade inflammation in adipose tissue links obesity with disturbances in insulin secretion and impaired glucose metabolism, therefore it indicates new therapeutic and preventive targets in both healthy and diabetic subjects. | 24675103 |