| CX3CR1 |
| LOCUS ID | 1524 | |||||||||||||
| GENE_SYMBOL | CX3CR1 | |||||||||||||
| GENE NAME | chemokine (C-X3-C mo | |||||||||||||
| SYNONYMNS | V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1 | |||||||||||||
| CHROMOSOME | 3 | |||||||||||||
| HOMOLOGENE ID | 20350 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Fractalkine and CX3CR1 upregulation were demonstrated in an early stage of diabetic kidney. These upregulation, as well as Urinary albumin excretion, were suppressed by treatments with temocapril and aminoguanidine for 8 weeks. These findings suggest that fractalkine expression and CX3CR1-positive cell infiltration in diabetic kidneys might play an important role for progression of diabetic nephropathy. | 15153757 |
| Insulin resistance and inflammation | 1. Cx3cr1-/- mice also had improved insulin sensitivity at hyperinsulinemic-euglycemic clamp, with higher glucose infusion rate, rate of disposal, and hepatic glucose production suppression compared to WT mice. | 26393344 |