CXCL10
LOCUS ID3627
GENE_SYMBOLCXCL10
GENE NAMEchemokine (C-X-C mot
SYNONYMNSC7, IFI10, INP10, IP-10, crg-2, mob-1, SCYB10, gIP-10
CHROMOSOME4
HOMOLOGENE ID1203
microRNAsNANA
GENE SUMMARY
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. while IL-10, CXCL8, CXCL9, CXCL10 and adiponectin concentrations of DN were significantly higher than patients without diabetic nephropathy (NDN) and control subjects (all P < 0.05).17425653
Neuropathy1. RT-PCR demonstrated that elevated levels of mRNA of CCL2, CXCL10 or TLR4 in the spinal cord of DM mice decreased significantly when DM mice were treated with CoQ10.23684663
Insulin resistance and inflammation1. The correlations between ANGPT2 and CXCL10, and NAFLD features were dependent on insulin resistance and T2D, but for the other genes the correlation with at least one NAFLD feature remained significant after correcting for the covariates.25664838