| CXCL14 |
| LOCUS ID | 9547 | ||||||||||
| GENE_SYMBOL | CXCL14 | ||||||||||
| GENE NAME | C-X-C motif chemokin | ||||||||||
| SYNONYMNS | KEC KS1 BMAC BRAK NJAC MIP2G MIP-2g SCYB14 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 3592 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated th |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. CXCL14 expression is elevated in white adipose tissue (WAT) of high-fat diet (HFD)-fed obese mice and leptin-system defective mutant mice. | 19251036 |