| CXCL5 |
| LOCUS ID | 6374 | ||||||||||||||||
| GENE_SYMBOL | CXCL5 | ||||||||||||||||
| GENE NAME | chemokine (C-X-C mot | ||||||||||||||||
| SYNONYMNS | SCYB5, E-78 | ||||||||||||||||
| CHROMOSOME | 4 | ||||||||||||||||
| HOMOLOGENE ID | 88672 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSe |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Increased urinary levels of CXCL5, CXCL8 and CXCL9 in patients with Type 2 diabetic nephropathy. 2. These suggest that these three CXC chemokines may be involved in the progression of human Type 2 diabetic nephropathy and that CXCL5 may be of use for telling diabetic nephropathy from primary renal diseases. | 18413205 |
| Atherosclerosis | 1. Serum CXCL5 is an important determinant of carotid artery intima-media thickness (IMT) in patients with type 2 diabetes. | 21609350 |
| Insulin resistance and inflammation | 1. CXCL5 blocks insulin signaling by activating the Jak2/STAT5/SOCS2 pathway. | 19356715 |