| CXCR3 |
| LOCUS ID | 2833 | ||||||||||
| GENE_SYMBOL | CXCR3 | ||||||||||
| GENE NAME | C-X-C motif chemokin | ||||||||||
| SYNONYMNS | GPR9 MigR CD182 CD183 Mig-R CKR-L2 CMKAR3 IP10-R | ||||||||||
| CHROMOSOME | X | ||||||||||
| HOMOLOGENE ID | 1153 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding diffe |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. CXCR3(-/-) mice exhibited lower fasting glucose and improved glucose tolerance compared with WT-HFD mice, despite similar body mass. | 24124129 |