| CXCR4 |
| LOCUS ID | 7852 | ||||||||||
| GENE_SYMBOL | CXCR4 | ||||||||||
| GENE NAME | C-X-C motif chemokin | ||||||||||
| SYNONYMNS | FB22 HM89 LAP3 LCR1 NPYR WHIM CD184 LAP-3 LESTR NPY3R NPYRL WHIMS HSY3RR NPYY3R D2S201E | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 20739 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We report our finding that the chemokine (C-X-C motif) ligand 12 (CXCL12, also known as stromal cell-derived factor 1), identified from 3T3-L1 adipocyte conditioned medium, induces monocyte migration via its receptor chemokine (C-X-C motif) receptor 4 (CXCR4). | 24744121 |