| CYP1A1 |
| LOCUS ID | 1543 | |||||||||||||
| GENE_SYMBOL | CYP1A1 | |||||||||||||
| GENE NAME | cytochrome P450 fami | |||||||||||||
| SYNONYMNS | AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX | |||||||||||||
| CHROMOSOME | 15 | |||||||||||||
| HOMOLOGENE ID | 68062 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metab |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. This study provides further evidence that genetic variation of the leukotriene (LT) pathway, PON1, and CYP1A1 can modulate the atherogenic processes and eventually increase the risk of CAD in our study population. | 25902778 |
| Atherosclerosis | 1. This study provides further evidence that genetic variation of the leukotriene (LT) pathway, PON1, and CYP1A1 can modulate the atherogenic processes and eventually increase the risk of CAD in our study population. | 25902778 |