| CYP2C19 |
| LOCUS ID | 1557 | ||||||||||
| GENE_SYMBOL | CYP2C19 | ||||||||||
| GENE NAME | cytochrome P450 fami | ||||||||||
| SYNONYMNS | CPCJ, CYP2C, P450C2C, CYPIIC17, CYPIIC19, P450IIC19 | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 133565 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygeses which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metaboli |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. The CYP2C19 poor metabolizer genotype was found to be an independent risk factor for DR only in women when patients were stratified by sex (OR, 4.18; 95% CI, 1.42-12.26). | 24113215 |