| CYP2E1 |
| LOCUS ID | 1571 | ||||||||||
| GENE_SYMBOL | CYP2E1 | ||||||||||
| GENE NAME | cytochrome P450 fami | ||||||||||
| SYNONYMNS | CPE1 CYP2E P450-J P450C2E | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 68089 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon t |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Markers of oxidative stress such as elevated CYP2E1 activity and protein amounts, lipid peroxidation, protein carbonylation, nitration, and glycation with increased phospho-JNK were all markedly elevated only in the livers of HFD-fed WT mice. | 22668639 |