| DAB2 |
| LOCUS ID | 1601 | ||||||||||
| GENE_SYMBOL | DAB2 | ||||||||||
| GENE NAME | DAB adaptor protein | ||||||||||
| SYNONYMNS | DOC2 DOC-2 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 1026 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for bindi |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Dab2 expression was upregulated in M2 macrophages and suppressed in M1 macrophages isolated from both mice and humans, and genetic deletion of Dab2 predisposed macrophages to adopt a proinflammatory M1 phenotype | 26927671 |