| DCD |
| LOCUS ID | 117159 | ||||||||||
| GENE_SYMBOL | DCD | ||||||||||
| GENE NAME | dermcidin | ||||||||||
| SYNONYMNS | PIF,AIDD,DSEP,HCAP,DCD-1 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 89039 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cance |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Chemerin and dermcidin, which have antimicrobial properties, are molecules that are also related to insulin resistance and inflammation. | 31002762 |