| DCN |
| LOCUS ID | 1634 | ||||||||||
| GENE_SYMBOL | DCN | ||||||||||
| GENE NAME | decorin | ||||||||||
| SYNONYMNS | CSCD, PG40, PGII, PGS2, DSPG2, SLRR1B | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 22430 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Decorin, a protein similar to podocan, also belongs to the SLRP family and is highly expressed in adipose tissues. It is associated with obesity, type 2 diabetes, and diabetic nephropathy. | 29264529 |