| Complication | Evidence | PMID |
| Nephropathy | 1. The present study demonstrated for the first time that the suppression of ADMA by DDAH overexpression could improve tubulointerstitial ischaemia and subsequent renal damage in experimental diabetic nephropathy. 2. Substitution of DDAH protein or enhancement of its activity may become a novel therapeutic strategy for the treatment of early diabetic nephropathy. | 19015171 |
| Retinopathy | 1. It can be concluded that PRMT-I and DDAHs-induced upregulation of ADMA levels might be involved in ROS- and RAS-mediated diabetic retinopathy. | 19748504 |
| Insulin resistance and inflammation | 1. Results provide the first direct evidence that the DDAH1 pathway has a marked effect on hepatic lipogenesis and steatosis induced by HFD feeding ; Studies suggest that strategies to increase DDAH1 activity in hepatocytes may provide a novel approach to attenuate NAFLD development and DDAH1 Protects Against High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice. | 27565538 |
