| DHRS9 |
| LOCUS ID | 10170 | ||||||||||
| GENE_SYMBOL | DHRS9 | ||||||||||
| GENE NAME | dehydrogenase/reduct | ||||||||||
| SYNONYMNS | RDHL RDH15 RDH-E2 RDHTBE SDR9C4 RDH-TBE RETSDR8 3ALPHA-HSD 3-alpha-HSD | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 26079 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repress |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Lipid metabolism genes associated with insulin resistance were significantly up-regulated, with confirmed increases in DHRS9 (2.5-fold), UCLH1 (2.6-fold), and FADS1 (2.8-fold) expression. | 22344199 |