| DKK3 |
| LOCUS ID | 27122 | ||||||||||
| GENE_SYMBOL | DKK3 | ||||||||||
| GENE NAME | dickkopf WNT signali | ||||||||||
| SYNONYMNS | RIG REIC | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 8303 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Further investigation indicated that specific overexpression of DKK3 in hepatocytes enhanced insulin sensitivity and glucose tolerance, reduced the inflammatory response, and ameliorated the imbalance of lipid metabolism in response to HFD or genetic defects. | 27016281 |