DLK1
LOCUS ID8788
GENE_SYMBOLDLK1
GENE NAMEdelta like non-canon
SYNONYMNSDLK, FA1, ZOG, pG2, DLK-1, PREF1, Delta1, Pref-1
CHROMOSOME14
HOMOLOGENE ID2846
microRNAsNANA
GENE SUMMARY
This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdomi

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Delta-like homolog 1 (DLK1), also called preadipocyte factor 1, prevents adipocyte differentiation and has been considered a molecular gatekeeper of adipogenesis. A DLK1 complex genomic defect was identified in five women from a single family with central precocious puberty (CPP) and increased body fat percentage.30462238
Insulin resistance and inflammation1. Instead of an adipogenic inhibitor, Dlk1 should be regarded as a factor causally linked to obesity and insulin resistance, and may be used to predict development of type 2 diabetes.31383551