| DLK1 |
| LOCUS ID | 8788 | |||||||||||||
| GENE_SYMBOL | DLK1 | |||||||||||||
| GENE NAME | delta like non-canon | |||||||||||||
| SYNONYMNS | DLK, FA1, ZOG, pG2, DLK-1, PREF1, Delta1, Pref-1 | |||||||||||||
| CHROMOSOME | 14 | |||||||||||||
| HOMOLOGENE ID | 2846 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdomi |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. Delta-like homolog 1 (DLK1), also called preadipocyte factor 1, prevents adipocyte differentiation and has been considered a molecular gatekeeper of adipogenesis. A DLK1 complex genomic defect was identified in five women from a single family with central precocious puberty (CPP) and increased body fat percentage. | 30462238 |
| Insulin resistance and inflammation | 1. Instead of an adipogenic inhibitor, Dlk1 should be regarded as a factor causally linked to obesity and insulin resistance, and may be used to predict development of type 2 diabetes. | 31383551 |