| DNM1L |
| LOCUS ID | 10059 | ||||||||||
| GENE_SYMBOL | DNM1L | ||||||||||
| GENE NAME | dynamin 1 like | ||||||||||
| SYNONYMNS | DLP1 DRP1 DVLP EMPF OPA5 EMPF1 DYMPLE HDYNIV | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 6384 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Alterations in the mitochondrial membrane lipid composition by palmitate provoked DRP1 oligomerization and mitochondrial fission. Attenuating palmitate-induced mitochondrial fragmentation enhanced inflammatory response in macrophages. Therefore, mitochondrial fragmentation may be a protective mechanism to restrain palmitate-induced inflammation. | 29360568 |