| DNMT1 |
| LOCUS ID | 1786 | |||||||||||||
| GENE_SYMBOL | DNMT1 | |||||||||||||
| GENE NAME | D (cytosine-5-)-meth | |||||||||||||
| SYNONYMNS | AIM, DNMT, MCMT, CXXC9, HSN1E, ADCADN | |||||||||||||
| CHROMOSOME | 19 | |||||||||||||
| HOMOLOGENE ID | 124071 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic D. This protein is the major enzyme responsible for maintaining methylation patterns following D replication and shows a preference for hemi-methylated D. Methylation of D is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxi |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. expressions of UHRF1 and DNMT1 were increased in DN patients. | 26049093 |
| Insulin resistance and inflammation | 1. Obesity-induced, pro-inflammatory cytokines promote DNMT1 expression and its enzymatic activity. | 26139044 |