| DOCK2 |
| LOCUS ID | 1794 | ||||||||||
| GENE_SYMBOL | DOCK2 | ||||||||||
| GENE NAME | dedicator of cytokin | ||||||||||
| SYNONYMNS | IMD40 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 37984 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Mechanistically, DOCK2 appeared to regulate brown adipocyte differentiation because increased preadipocyte differentiation to brown adipocytes in interscapular and inguinal fat was observed in DOCK2-/- mice, as compared with WT. | 28716822 |