DRAM1
LOCUS ID55332
GENE_SYMBOLDRAM1
GENE NAME DNA damage regulate
SYNONYMNSDRAM
CHROMOSOME12
HOMOLOGENE ID41255
microRNAsNANA
GENE SUMMARY
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. Moreover, we demonstrate that the 3 non-canonical autophagy genes DRAM1, VAMP8 and TP53INP1 as differentially expressed between healthy and T2DM groups during myoblast differentiation, and that T53INP1 knock-down alters expression of both pro-and anti-apoptotic genes.31160616