| DRAM1 |
| LOCUS ID | 55332 | ||||||||||
| GENE_SYMBOL | DRAM1 | ||||||||||
| GENE NAME | DNA damage regulate | ||||||||||
| SYNONYMNS | DRAM | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 41255 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. Moreover, we demonstrate that the 3 non-canonical autophagy genes DRAM1, VAMP8 and TP53INP1 as differentially expressed between healthy and T2DM groups during myoblast differentiation, and that T53INP1 knock-down alters expression of both pro-and anti-apoptotic genes. | 31160616 |