| DUSP1 |
| LOCUS ID | 1843 | ||||||||||
| GENE_SYMBOL | DUSP1 | ||||||||||
| GENE NAME | dual specificity pho | ||||||||||
| SYNONYMNS | HVH1 MKP1 CL100 MKP-1 PTPN10 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 3254 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, m |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. The levels of DUSP1 mRNA and protein were significantly increased in obese subjects with concomitant decrease in the phosphorylation of p38 MAPK (p-p38 MAPK) and PGC-1? and an increase in the levels of phospho-JNK (p-JNK) and phospho-ERK (p-ERK). | 25370852 |