DUSP12
LOCUS ID11266
GENE_SYMBOLDUSP12
GENE NAMEdual specificity pho
SYNONYMNSYVH1 DUSP1
CHROMOSOME1
HOMOLOGENE ID5238
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1. hepatocyte specific DUSP12-deficient mice exhibit high-fat diet (HFD)-induced and high-fat high-cholesterol diet-induced hyperinsulinemia and liver steatosis and decreased insulin sensitivity.30820969