| DUSP12 |
| LOCUS ID | 11266 | ||||||||||
| GENE_SYMBOL | DUSP12 | ||||||||||
| GENE NAME | dual specificity pho | ||||||||||
| SYNONYMNS | YVH1 DUSP1 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 5238 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. hepatocyte specific DUSP12-deficient mice exhibit high-fat diet (HFD)-induced and high-fat high-cholesterol diet-induced hyperinsulinemia and liver steatosis and decreased insulin sensitivity. | 30820969 |