| DUSP14 |
| LOCUS ID | 11072 | ||||||||||
| GENE_SYMBOL | DUSP14 | ||||||||||
| GENE NAME | dual specificity pho | ||||||||||
| SYNONYMNS | MKP6 MKP-L | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 5100 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) cla |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Insulin resistance, hepatic lipid accumulation, and concomitant inflammatory responses, key pathological processes involved in NAFLD development, were significantly ameliorated by hepatocyte-specific DUSP14 overexpression (DUSP14-HTG) in high-fat diet (HFD)-induced or genetically obese mouse models. | 29077210 |