| DUSP5 |
| LOCUS ID | 1847 | ||||||||||
| GENE_SYMBOL | DUSP5 | ||||||||||
| GENE NAME | dual specificity pho | ||||||||||
| SYNONYMNS | DUSP HVH3 | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 3256 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show dis |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We report that DUSP5, an ERK1/2 phosphatase, was induced in epididymal white adipose tissue (WAT) in response to diet-induced obesity. | 29018280 |