EBF1
LOCUS ID1879
GENE_SYMBOLEBF1
GENE NAMEearly B-cell factor
SYNONYMNSEBF, COE1, OLF1, O/E-1
CHROMOSOME5
HOMOLOGENE ID7297
microRNAsNANA
GENE SUMMARY
EBF1 (EBF Transcription Factor 1) is a Protein Coding gene. Diseases associated with EBF1 include Plasmacytoma and B-Lymphoblastic Leukemia/Lymphoma With Etv6-Runx1. Among its related pathways are Adipogenesis and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and C2H2 zinc finger domain binding. An important paralog of this gene is EBF3.

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. This observed and replicated interaction between psychosocial stress and variation in the EBF1 gene may provide a biological hypothesis for the complex relationship between psychosocial stress, central obesity, diabetes, and cardiovascular disease.25271088
Insulin resistance and inflammation1. High-fat diet intervention in Ebf1(+/-) mice resulted in more pronounced WAT hypertrophy and attenuated insulin sensitivity compared with wild-type littermate controls. 0