| EBF1 |
| LOCUS ID | 1879 | |||||||||||||
| GENE_SYMBOL | EBF1 | |||||||||||||
| GENE NAME | early B-cell factor | |||||||||||||
| SYNONYMNS | EBF, COE1, OLF1, O/E-1 | |||||||||||||
| CHROMOSOME | 5 | |||||||||||||
| HOMOLOGENE ID | 7297 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| EBF1 (EBF Transcription Factor 1) is a Protein Coding gene. Diseases associated with EBF1 include Plasmacytoma and B-Lymphoblastic Leukemia/Lymphoma With Etv6-Runx1. Among its related pathways are Adipogenesis and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and C2H2 zinc finger domain binding. An important paralog of this gene is EBF3. |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. This observed and replicated interaction between psychosocial stress and variation in the EBF1 gene may provide a biological hypothesis for the complex relationship between psychosocial stress, central obesity, diabetes, and cardiovascular disease. | 25271088 |
| Insulin resistance and inflammation | 1. High-fat diet intervention in Ebf1(+/-) mice resulted in more pronounced WAT hypertrophy and attenuated insulin sensitivity compared with wild-type littermate controls. | 0 |