| EBF2 |
| LOCUS ID | 64641 | ||||||||||
| GENE_SYMBOL | EBF2 | ||||||||||
| GENE NAME | early B-cell factor | ||||||||||
| SYNONYMNS | COE2, OE-3, EBF-2, O/E-3 | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 56471 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved D binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. We demonstrate upregulation of the Knot ortholog EBF2 in glomeruli of human diabetic nephropathy patients and a mouse ob/ob diabetes model. | 26190114 |