| EGF |
| LOCUS ID | 1950 | ||||||||||||||||
| GENE_SYMBOL | EGF | ||||||||||||||||
| GENE NAME | epidermal growth fac | ||||||||||||||||
| SYNONYMNS | URG, HOMG4 | ||||||||||||||||
| CHROMOSOME | 4 | ||||||||||||||||
| HOMOLOGENE ID | 1483 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. In serum, MCP-1, FGF-2, VEGF, and EGF levels were elevated above controls at all stages of DN. | 26116588 |
| Retinopathy | 1. Serum ET, Follistatin and EGF were significantly higher in DR patients as compared to those without DR and should be considered to be significant biomarkers of retinal complications in diabetes mellitus. | 30158034 |
| Insulin resistance and inflammation | 1. First, next to leptin, the circulating mediators chemerin, tissue inhibitor of metalloproteinase 1, EGF and TNF receptor 2 were identified as novel inflammatory mediators that are increased in childhood obesity. | 22806355 |