| EIF4EBP1 |
| LOCUS ID | 1978 | ||||||||||
| GENE_SYMBOL | EIF4EBP1 | ||||||||||
| GENE NAME | eukaryotic translati | ||||||||||
| SYNONYMNS | BP-1, 4EBP1, 4E-BP1, PHAS-I | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 3021 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various sigls including UV irradiation and insulin sigling, resulting in it |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. These findings suggest the possibility that resveratrol exerts antiproliferative, antihypertrophic effects by activating AMPK and reducing 4E-BP1 and S6 phosphorylation, thus suppressing the development and progression of DN. | 20332614 |