| ELMO1 |
| LOCUS ID | 9844 | |||||||||||||
| GENE_SYMBOL | ELMO1 | |||||||||||||
| GENE NAME | engulfment and cell | |||||||||||||
| SYNONYMNS | CED12, CED-12, ELMO-1 | |||||||||||||
| CHROMOSOME | 7 | |||||||||||||
| HOMOLOGENE ID | 56685 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. This study first investigated the association of ELMO1 gene polymorphisms with DN in a Chinese population, supporting its key role as a candidate gene in the susceptibility of DN. | 20019166 |
| Neuropathy | 1. The aim of this study was to investigate the association of a genetic polymorphism of monocyte chemoattractant protein-1 (CCL2-rs3917887), chemokine receptor 5 (CCR5-rs1799987), engulfment and cell mortality (ELMO1-rs74130), and interleukin-8 (IL8-rs4073) with the development of DN among Malaysian type 2 diabetes mellitus (T2DM) patients. | 30713847 |