| ENPP2 |
| LOCUS ID | 5168 | ||||||||||
| GENE_SYMBOL | ENPP2 | ||||||||||
| GENE NAME | ectonucleotide pyrop | ||||||||||
| SYNONYMNS | ATX, NPP2, ATX-X, PDNP2, LysoPLD, AUTOTAXIN, PD-IALPHA | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 4526 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcino |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. ATX is a multifunctional ectoenzyme and is involved in many patho-physiological conditions such as cancer, neuropathy pain, lymphocyte tracking in lymph nodes, obesity, diabetes and embryonic blood vessel formation. 2. In serum or plasma, LPA is predomintly produced by a plasma enzyme called autotaxin (ATX). ATX is a multifunctional ectoenzyme and is involved in many patho-physiological conditions such as cancer, neuropathy pain, lymphocyte tracking in lymph nodes, obesity, diabetes and embryonic blood vessel formation. | 18621144 |