| ERBB3 |
| LOCUS ID | 2065 | ||||||||||
| GENE_SYMBOL | ERBB3 | ||||||||||
| GENE NAME | erb-b2 receptor tyro | ||||||||||
| SYNONYMNS | HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErb | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 20457 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferat |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. In , CTSH/rs3825932 and ERBB3/rs2292239 SNPs were associated with reduced risk of progression to PDR and two-step progression of DR on the ETDRS scale accordingly. | 26245339 |