| ERCC1 |
| LOCUS ID | 2067 | |||||||||||||
| GENE_SYMBOL | ERCC1 | |||||||||||||
| GENE NAME | excision repair cros | |||||||||||||
| SYNONYMNS | UV20, COFS4, RAD10 | |||||||||||||
| CHROMOSOME | 19 | |||||||||||||
| HOMOLOGENE ID | 1501 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of D lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the D lesion. The heterodimeric endonuclease is also involved in recombinational D repair and in the rep |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. ERCC1 and ERCC4 may play important roles in the development of diabetic retinopathy and nephropathy. | 23028342 |
| Retinopathy | 1. ERCC1 and ERCC4 may play important roles in the development of diabetic retinopathy and nephropathy. | 22228707 |