| ERCC4 |
| LOCUS ID | 2072 | |||||||||||||
| GENE_SYMBOL | ERCC4 | |||||||||||||
| GENE NAME | excision repair cros | |||||||||||||
| SYNONYMNS | XPF, RAD1, FANCQ, ERCC11 | |||||||||||||
| CHROMOSOME | 16 | |||||||||||||
| HOMOLOGENE ID | 3836 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific D repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. ERCC1 and ERCC4 may play important roles in the development of diabetic retinopathy and nephropathy. | 22228707 |
| Retinopathy | 1. ERCC1 and ERCC4 may play important roles in the development of diabetic retinopathy and nephropathy. | 22228707 |